
LifeStrands Genomics Australia offers a variety of molecular tests including cutting edge Next Generation Sequencing assays (under the trademark OncoStrands® brand), various PCR based tests, and relevant immunohistochemical stains.
Next Generation Sequencing Assays
- OncoStrands® Essential Combined (DNA + CNV + Fusions) ( brochure )
- A 50 gene targeted NGS panel covering key cancer related genes for
different tumour types including those in lung, colon, skin (melanoma),
urinary bladder, thyroid, brain, etc. The panel covers DNA hotspots from
45 genes, CNVs from 14 genes and fusions from 18 genes.
- A 50 gene targeted NGS panel covering key cancer related genes for
- OncoStrands® Essential DNA
- This assay covers the DNA only (mutations and CNV) component of the
above assay and can be performed as a standalone test.
- This assay covers the DNA only (mutations and CNV) component of the
- OncoStrands® Essential Fusion (RNA – Fusions
only)- This assay covers the RNA only (fusions) component of the above assay
and can be performed as a standalone test.
- This assay covers the RNA only (fusions) component of the above assay
- OncoStrands® DNA 68
- A 68 gene hybrid capture DNA NGS panel with coverage of full coding
regions of 68 key cancer related genes (plus TERT promoter region)
including BRCA1 and BRCA2. Can be ordered in combination with the
Essential Fusion Panel (please see above) if screening for fusions is
clinically important.
- A 68 gene hybrid capture DNA NGS panel with coverage of full coding
- OncoStrands® Extended ( brochure )
- A 108 gene hybrid capture DNA NGS panel with a coverage of full coding
regions of 103 genes, including BRCA1 and BRCA 2, and many other DNA
damage repair genes. The assay also provides accurate MSI score. The
gene contents are particularly useful for tumours in prostate, breast,
ovary and fallopian tube, pancreas, biliary tract, uterus, and colon.
Can be ordered in combination with the Essential Fusion Panel (see
above) if screening for fusions is clinically important.
- A 108 gene hybrid capture DNA NGS panel with a coverage of full coding
- OncoStrands® Comprehensive Fusion (RNA – Fusions only)
- This is the Illumina TruSight™ RNA Fusion Panel. The
assay offers comprehensive analysis of known and novel fusion
transcripts in 501 genes and is well suited for genomic profiling of
fusions in a pan-cancer setting, particularly for all types of sarcomas.
- This is the Illumina TruSight™ RNA Fusion Panel. The
- OncoStrands® Comprehensive ( brochure )
- This is the Illumina TSO500 Panel offering comprehensive genomic
analysis of 523 genes and targets SNVs, CNVs, fusions, MSI, and TMB. The
assay provides an extensive coverage of NCCN biomarker testing
guidelines, genes associated with FDA approved targeted therapies, and
clinical trials matching for a variety of tumours.
- This is the Illumina TSO500 Panel offering comprehensive genomic
- OncoStrands Comprehensive HRD
- This is the Illumina TSO500 HRD Panel offering comprehensive genomic
analysis of 523 genes and targets SNVs, CNVs, fusions, MSI, TMB, and
HRD. The assay provides an extensive coverage of NCCN biomarker
testing guidelines, genes associated with FDA approved targeted
therapies, and clinical trials matching for a variety of tumours.
Additionally, tumour HRD status is determined to guide PARPi
therapies.
- This is the Illumina TSO500 HRD Panel offering comprehensive genomic
- OncoStrands Neuro-Oncology
- A 100 gene hybrid capture DNA NGS panel covering the full coding regions
of 94 genes, hotspot regions in 5 genes, and selected TERT promoter
alterations to assist CNS tumour classification as per the WHO 2021
guidelines. Additionally, the assay detects chromosome level copy number
changes in chromosomes 1p, 6, 7, 9, 10, 16, 17 and 19q. This panel is
suitable for testing both adult and paediatric CNS tumours.
- A 100 gene hybrid capture DNA NGS panel covering the full coding regions
PCR based Assays
- MLH1 Promoter Methylation
- MGMT Promoter Methylation
Immunohistochemical Stains
- ALK
- ROS1
- MMR (MLH1, PMS2, MSH2, MSH6)
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